One enzyme from two genes?

Genomics in Neurospora crassa: From One-Gene- One-Enzyme to 10,000 Genes

Neurospora crassa was the central organism in the development of biochemical genetics, providing a model system that established the relationship between genes and enzymes; it remains the best-studied filamentous fungus. This review focuses on the impact that the recent publication of a high-quality draft sequence of the N. crassa genome will have upon efforts to understand the biology of the f...

One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity.

The human enzyme paraoxonase-2 (PON2) has two functions, an enzymatic lactonase activity and the reduction of intracellular oxidative stress. As a lactonase, it dominantly hydrolyzes bacterial signaling molecule 3OC12 and may contribute to the defense against pathogenic Pseudomonas aeruginosa. By its anti-oxidative effect, PON2 reduces cellular oxidative damage and influences redox signaling, w...

Two chitin metabolic enzyme genes from Hyriopsis cumingii: cloning, characterization, and potential functions.

Chitin, the second most important natural polymer in the world, and its N-deacetylated derivative chitosan are found in a wide variety of organisms. These versatile biopolymers are associated with a broad range of biological functions. This article is the first to report the potential functions of 2 chitin metabolic enzyme genes from Hyriopsis cumingii. A chitinase-3 gene (Chi-3) and a chi...

The one gene-one enzyme hypothesis.

Visual Perception: One World from Two Eyes

Binocular vision requires us to match up the different views of the world seen by each eye. Computational models of primary visual cortex describe how the brain begins this process. Recurrent connections help suppress the response to false matches.